Women with HIV experience accelerated DNA aging, a phenomenon that can lead to poor physical function.
This is according to a study led by Stephanie Shiau, an assistant professor in the Department of Biostatistics and Epidemiology at the Rutgers School of Public Health, and which was published in The Journal of Infectious Diseases.
Globally, over 50 percent of individuals living with HIV are women, and women accounted for an estimated 46 percent of all new infections in 2022. Women with HIV experience higher rates of bone loss compared to women without the virus, which can place them at increased risk of fracture as they age, according to results from the Women’s Interagency HIV Study.
“Understanding the molecular mechanisms behind accelerated aging in people with HIV is crucial for developing targeted interventions and improving the quality of life for those living with the virus,” said Shiau.
Shiau said while accelerated aging has been reported in people with HIV, these studies have been primarily conducted among men and not women.
This study focused on a sample of 195 women with HIV ages 40 to 60, comparing them to a cohort of women without the virus, and conducted various analyses to explore how markers of aging measured in blood were related to bone mineral density and measurements of physical function, such as muscle strength, walking speed, balance and endurance.
The study found that women with HIV were aging faster than their chronological age.
In both groups, women who couldn’t hold a single leg stand for 30 seconds displayed increased aging, suggesting potential links between accelerated aging and certain aspects of physical function and emphasizing the need for further research to confirm and comprehend these associations over time.
“The work demonstrates that women living with HIV experience an accelerated aging process at the DNA level, and that this aging process may be linked to functional outcomes,” said Shiau. “Future studies will need to see whether these findings are observed longitudinally.”
Co-authors of the study included researchers from collaborating institutions in New York, Illinois and California.
