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Kidney transplantation between donors and recipients with HIV is safe

Kidney transplantation between donors and recipients with HIV was safe and noninferior to transplantation from donors without HIV. These findings offer evidence to support the expansion of the practice outside of research settings. 

Transmission electron micrograph of HIV-1 virus particles (colorized yellow/gold) replicating from an HIV-infected H9 T-cell (purple). Budding virus particles that have not yet separated from the cell appear as semi-circles. A separated, spherical immature particle is seen at center of the image. Image captured at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland

Kidney transplantation from deceased donors with HIV (HIV D+) to recipients with HIV (HIV R+) was safe and comparable to kidney transplantation from donors without HIV (HIV D-).

This is according to a study – “Safety of Kidney Transplantation from Donors with HIV” by Christine M. Durand, Allan Massie, Sander Florman, et al – that was published in the New England Journal of Medicine.

The clinical outcomes observed were consistent with smaller pilot studies, but this National Institutes of Health (NIH)-funded clinical trial was the first statistically powered to demonstrate noninferiority, which means that an approach being studied is as good as standard clinical practice.

Kidney transplants offer a survival benefit to people with HIV and end-stage kidney disease, but an organ shortage limits access. In addition, people with HIV face a higher risk of death while on the organ waitlist and have lower access to transplants than people without HIV.

This study enrolled 198 adults with HIV and end-stage kidney disease who received kidney transplants at 26 centers, comparing the outcomes of 99 study participants who had donors with HIV versus 99 whose donors did not have HIV. Transplants were completed between April 2018 and September 2021 and recipients were monitored subsequently for about three years.

The outcomes for overall survival, graft survival, and rejection events were similar between the two groups. After one year post-transplant, recipient survival was 94% in HIV D+/R+ and 95% in HIV D-/R+. At three years, recipient survival rates were 85% in HIV D+/R+ and 87% in HIV D-/R+. After one year post-transplant, graft survival was 93% in HIV D+/R+ and 90% HIV D-/R+. At three years post-transplant, graft survival rates were 84% in HIV D+/R+ and 80% in HIV D-/R+.

Finally, at one year post-transplant, rejection incidence was 13% in HIV D+/R+ and 21% HIV D-/R+ and at three years, 13% in HIV D+/R+ versus 21% in HIV D-/R+. Rates of serious adverse events, surgical site infections, surgical/vascular complications, and cancer were also comparable between the two groups. One case of a recipient who may have acquired a second genetically distinct HIV strain from their donor was observed, but there were no notable clinical consequences. 

The study was led by the Johns Hopkins University School of Medicine, Baltimore, and funded by NIH’s National Institute of Allergy and Infectious Diseases (NIAID).

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