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A third of trans masculine individuals on testosterone ovulate

In a study of trans masculine people who use testosterone and who no longer menstruate, 33% still showed signs of recent ovulation in the ovarian tissue.  

Photo by Amine M'siouri from Pexels.com

An examination of the ovarian tissue of trans masculine people (or those born female but do not identify as such) shows that 33% of them show signs of recent ovulation, despite being on testosterone and no longer menstruating.

This is according to a study – “One third of amenorrheic trans masculine people on testosterone ovulates” by Joyce Asseler and gynecologist Norah van Mello – that appeared in the journal Cell Reports Medicine.

Trans masculine people often use hormone treatment with testosterone to masculinize physically. This hormone usually stops them from menstruating. In that case, it is often assumed that ovulation does not take place anymore. 

Here, the researchers examined the ovarian tissue of transgender people who had their ovaries removed as part of their gender-affirming treatment. Those who engaged in the study had all used testosterone for at least one year prior to and at the time of the procedure.

In their analysis, the researchers found that 17 of the 52 study participants (33%) showed signs of recent ovulation in the ovarian tissue.  

“Testosterone apparently has a heterogenous effect on ovarian tissue. We don’t know why one person ovulates and another person doesn’t. In any case, we cannot explain this difference by the type of testosterone, or how long someone has been taking testosterone,” said Asseler.  

“The physical and mental consequences of an unplanned and unwanted pregnancy are enormous. It is important that trans masculine people and their healthcare providers are aware of this risk and act accordingly. Furthermore, this discovery can contribute to better care for trans masculine people who experience abdominal cramping,” Asseler ended. 

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